Antibiotics, Free Full-Text
€ 14.00 · 4.7 (415) · En stock
Por un escritor de hombre misterioso
(1) Background: To explore the impact of the degree of inflammation on voriconazole exposure in critically ill patients affected by COVID-associated pulmonary aspergillosis (CAPA); (2) Methods: Critically ill patients receiving TDM-guided voriconazole for the management of proven or probable CAPA between January 2021 and December 2022 were included. The concentration/dose ratio (C/D) was used as a surrogate marker of voriconazole total clearance. A receiving operating characteristic (ROC) curve analysis was performed by using C-reactive protein (CRP) or procalcitonin (PCT) values as the test variable and voriconazole C/D ratio > 0.375 (equivalent to a trough concentration [Cmin] value of 3 mg/L normalized to the maintenance dose of 8 mg/kg/day) as the state variable. Area under the curve (AUC) and 95% confidence interval (CI) were calculated; (3) Results: Overall, 50 patients were included. The median average voriconazole Cmin was 2.47 (1.75–3.33) mg/L. The median (IQR) voriconazole concentration/dose ratio (C/D) was 0.29 (0.14–0.46). A CRP value > 11.46 mg/dL was associated with the achievement of voriconazole Cmin > 3 mg/L, with an AUC of 0.667 (95% CI 0.593–0.735; p < 0.001). A PCT value > 0.3 ng/mL was associated with the attainment of voriconazole Cmin > 3 mg/L (AUC 0.651; 95% CI 0.572–0.725; p = 0.0015). (4) Conclusions: Our findings suggest that in critically ill patients with CAPA, CRP and PCT values above the identified thresholds may cause the downregulation of voriconazole metabolism and favor voriconazole overexposure, leading to potentially toxic concentrations.
Natural Products as Platforms To Overcome Antibiotic Resistance
BioActive Group - Research
1,000+ Antibiotic Free Stock Photos, Pictures & Royalty-Free Images - iStock
Print Materials, Antibiotic Use
Antibiotic Prophylaxis in Infants with Grade III, IV, or V Vesicoureteral Reflux
Antibiotic-free' labels posing pitfalls for aquaculture
Which Restaurants Serve Antibiotic Free Meat? - Feed Them Wisely
Antibiotic drug-resistance as a complex system driven by socio-economic growth and antibiotic misuse
Highlight, take notes, and search in the book In this edition, page numbers are just like the physical edition
Antibiotic Basics for Clinicians
Antibiotic stewardship in the ICU: time to shift into overdrive, Annals of Intensive Care
The meat industry's antibiotic drug problem, explained - Vox
Antibiotic resistance, Definition, Mechanisms, Examples, & Facts
Subway To Serve Only Antibiotic-Free Chicken
Antibiotic - Wikipedia
What's in Your Beef? A Lot of Antibiotics, Says Food Industry Survey